Science is changing rapidly and new transdisciplinary approaches are resulting in transformative change across domains. Health and medicine have begun to embrace convergent approaches that involve expertise from non-traditional biomedical disciplines. This has resulted in new methods and findings that could not have happened a decade earlier. Informatics and advanced analytics are poised to contribute to these changes by bringing sophisticated techniques to partnerships in the biomedical realm. This talk will cover some advances being made and a vision for future.